vascular system, extracellular matrix, neurogenesis (brain development), glucose homeostasis, synaptic transmission and olfactory sensory perception categories in the GOC modules (Figure 3C), while the LOC modules are enriched for genes involved in nerve myelination, cell-cycle, γ-aminobutyricacid (GABA) metabolism, and neurotrophin signaling (Figure 3C). Many of these functional categories have previously been implicated in LOAD and/or CNS-related function (Ansari and Scheff, 2010; Cechetto et al., 2008; Dodel et al., 2003; Luchsinger, 2008; Morawski et al., 2012; Schiffman et al., 2002), again reinforcing the complex multi-factorial basis of the underlying pathophysiology. The functional categories enriched in the conserved modules included “muscle contraction” (actin-related system), coated vesicle, cadherin and zinc ion metabolism (Figure 3C).
