Chunk #47 — SUD Prevalence and qEEG Changes — qEEG in Substance Use Disorders — P300 Abnormalities in Cocaine, Methamphetamine, Heroin Addiction, and Alcoholism
patient groups, the P300 was significantly reduced in amplitude relative to the P300 ERPs recorded from individuals with no history of alcohol or drug dependence. This study also demonstrated that continued abstinence from heroin and from cocaine and alcohol is also associated with a trend toward normalization of the P300. In a recent study of Papageorgiou et al. (2004) the P300 component was evaluated during the anticipatory period of a short memory task in 20 patients characterized by a past history of heroin dependence (6 months abstinence), in 18 current heroin users and in 20 matched healthy subjects. Abstinent heroin addicts exhibited a significant reduction of the P300 amplitude at the central frontal region, relative to the other two groups.
