The cross-sectional population-based samples KORA and SHIP were both genotyped for SNP rs2302382. In KORA, the regression analyses showed a trend for the presence of one A-allele to lead to an average increase of 0.12 BMI units (95%CI -0.04;0.28; p-value = 0.136) (Table 6). Similarly, stratification by WHO BMI categories underlined this trend (pCA-Test; asy = 0.037 for the comparison of BMI < 30 vs. BMI ≥ 30). In SHIP, however, the effect of the A-allele pointed into the opposite direction. In contrast to all previous findings, the A-allele of rs2302382 was estimated to decrease mean BMI units by 0.27 kg/m2 (95%CI -0.52; -0.24; p-value = 0.031; pCA-Test;asy = 0.039 for the comparison of BMI <30 vs. BMI ≥ 30 kg/m2).
