Chunk #71 — Background — Where and how the data were collected

Source

Construction of the model for the Genetic Analysis Workshop 14 simulated data: genotype-phenotype relationships, gene interaction, linkage, association, disequilibrium, and ascertainment effects for a complex phenotype.

Embedded

yes

Text

The data that were available for analysis at GAW14 included data collections from four different groups of investigators. Each of these geographically diverse groups had collected families diagnosed with KPD, but the criteria for diagnosis varied. Patients were classified as KPD based on the diagnosing physician's judgment. In all groups except the NYC group, ascertainment required at least two affected offspring to be present. The NYC group required four affected family members.