The SW networks always exhibit the lowest synchrony among the four topologies (Figures 2B,C). Importantly, the global synchronization in a network is not always a positive symptom. In the brain, for example, hypersynchronization of neurons is a phenotype of epilepsy (Netoff et al., 2004). In such cases, SW connectivity, such as that observed in the macroscopic wiring of the human cortex (Bullmore and Sporns, 2012), can be beneficial.
