mIPSC rise time (Fig. 4F) and decay time (Fig. 4G) between MOR N40 and D40 AD-iNs before or after acute ethanol application. These data suggest an ethanol-mediated increase in synaptic release in N40 AD-iNs, ultimately indicating a presynaptic effect. Taken together, acute (40 mM) ethanol application facilitates inhibitory synaptic transmission exclusively in N40 iNs, illustrating a genotypic difference in acute ethanol sensitivity for MOR variants.
