Here we present a comprehensive association study of nicotine dependence with SNP-based variation in the complete family of 16 nicotinic receptor subunits. This targeted study of the CHRN genes expands upon the coverage we previously attained in NICSNP, a large-scale case-control nicotine dependence association study consisting of the first high-density genome-wide association screen (GWAS) for nicotine dependence (Bierut et al., 2007) paired with an extensive candidate gene (CG) survey of 348 genes (Saccone et al., 2007a).
