a firm basis for implicating specific susceptibility variants, the identification of replicated associations can be of value in identifying candidate genes for further intensive genetic investigation and also for generating hypotheses concerning aetiology and pathophysiology. Both of the methods we have applied here, best corrected p-value and truncated product, confer this potential advantage. They are also both are applicable not just to genes but also to other definitions of functional units, for example groups of genes with related functions.
