We tested the top SNP at each of the loci showing genome-wide significant association (P < 5 × 10−8) with FEV1 or FEV1/FVC for association with the other of the two traits, and with FVC in the stage 1 studies (Table 3). In addition to being associated with FEV1, rs10516526 in GSTCD was associated with FVC (P = 2.53 × 10−7) but showed no discernible effect on FEV1/FVC.
