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Chunk #20 — RESULTS — Effect of CNIH-2 deletion on synaptic proteins

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Cornichon proteins determine the subunit composition of synaptic AMPA receptors.
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We also re-examined the distribution of CNIH-2 protein in the hippocampus, using an antibody we recently generated using the same epitope as Kato et al. (Kato et al., 2010a). As in our previous study (Shi et al., 2010), the large majority of CNIH-2 was intracellular. However, with the new antibody, CNIH-2 could also be detected on the cell surface (Figure 5G).