Beyond the SNPs reported in Table 1, other strong signals in genes with plausible biological relevance are OPCML (rs11223249; P = 3.52 × 10−5) an opioid binding protein; CTNNA2 (rs2861913; P = 6.95 × 10−5), the alpha-N-catenin that interacts with cadherin proteins in essential brain functions (63-65); and IKBKAP (rs10118853; P = 5.11 × 10−5), a gene that causes familial dysautonomia, a sensory and autonomic neuropathy.
