In our review of 20 years ago, we were also remiss in failing to recognize an insidious problem in the field: the lack of diversity in genetics research, among our participants and research community, and the potential for harm this would create. In this paper, I provide an update on advances that have occurred, and, in the spirit of Karl Popper, I make risky new predictions about the potential applications of genetics in the future, which I believe will be far-reaching, with drastic impact on our lives. Finally, I discuss the ethical implications that have become increasingly pressing as the field has advanced.