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Chunk #29 — Methods — Ancestry Determination

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Identification of 15 genetic loci associated with risk of major depression in individuals of European descent.
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Supplementary Figure 2a shows the proportion of variance explained by each principal component, and Supplementary Figure 2b shows the proportion of each component’s variance that is explained by country of ancestry, for a set of individuals reporting four grandparents from a single country. The first 5 PCs are largely explained by geographic ancestry, while higher order PCs are not.