Participants were part of the customer base of 23andMe, Inc., a consumer genetics company. This cohort has been described in detail elsewhere27,28. Participants provided informed consent and participated in the research online. The protocol was approved by an external AAHRPP accredited IRB, Ethical and Independent Review Services. The discovery cohort was selected from participant data available in January 2015, and the replication cohort was selected in January 2016 from additional data available at that time.
