to obtain optimal stimulation parameters. In vivo recordings of VTA-projecting DLPfcx neurons do fire spontaneously around 4–6 Hz (Pistis et al., 2001) and a TMS stimulus frequency of 10 Hz could be a reasonable frequency to obtain a significant increase in VTA-projecting neurons aimed at stimulating the “deficient” dopamine system and its post-synaptic counterpart (i.e., MSN of the Nacc).