range. The change in the predicted global GMV and WMV when shifting from no daily alcohol consumption to one daily alcohol unit was less than 0.03 standard deviations. However, the observed associations between alcohol intake and global IDPs increase as the number of daily units increases. An increase from one to two daily units is associated with a decrease of 0.127 and 0.074 standard deviations in predicted global GMV and WMV, respectively. A change from two to three daily units is associated with a 75% greater decrease of 0.223 and 1.28 standard deviations in GMV and WMV, respectively. Table 3 benchmarks the predicted effect magnitudes against the effects associated with aging for an average 50-year-old UKB participant, based on our regression models in the full sample. Table 4 replicates these results using the models that exclude individuals who consume a high level of alcohol. For illustration, the effect associated with a change from one to two daily alcohol units is equivalent to the effect of aging 2 years (or 1.7 years in the model that excludes individuals who consume a high level of alcohol), where the increase from two to three daily units is equivalent to aging 3.5 years (or
