these, 518 were differentially expressed (padj < 0.2) in astrocytes in our snRNA-seq data, 861 in oligodendrocytes, 318 in D1 neurons, and 329 in D2 neurons. Differentially expressed genes within an associated locus are more likely than the others to play a role in these traits. Among these, genes whose expression is also associated with a nearby genetic variant are even more likely to be potential driver genes for AUD (Fig. 5A). Variants within open chromatin near such differentially expressed genes are strong candidates for those that affect the traits.
