is associated with a significant increase in c-fos mRNA activation in the orbitofrontal cortex, in contrast to decreases seen in other regions of the frontal cortex (including the PFC) (Campeau et al., 2002). Like other limbic cortices, the orbitofrontal cortex has potential polysynaptic connections with subcortical limbic stress effector pathways (Price, 2007), and increased engagement may play a role in dampening stress responses.
