studies targeting other subunits will be of great interest. Remarkably, many other ethanol-induced behaviors remain unaltered in mice with genetically modified GABAA receptors. For instance, the δ-GABAA receptors do not appear necessary for the discriminative stimulus effects of ethanol or substitution by barbiturates, benzodiazepines, and neuroactive steroids in knockout mice (Shannon et al. 2004). One caveat to these studies is that observed effects or lack of effects may be due to compensatory changes that are sometimes observed in knockout models and should be taken into consideration. Nonetheless, these studies implicate GABAA receptor subtypes in some behavioral actions of ethanol.
