where ΔBP was approximately 9%. This is more than half of the response seen with amphetamine 16, a drug that potently enhances synaptic DA by acting on the DA transporter. This relative potency is in agreement with direct measures obtained by brain microdialysis in experimental animals 9,16. In contrast, AA subjects did not show an alcohol-induced displacement of the radioligand in any region. Inclusion of the BAC at 45 min as a covariate in the statistical analysis of the %ΔBP data did not influence the main effect of genotype (F[1,19]=9.7, p=0.0057). The BAC at 45 min per se showed a trend for a significant effect on the %ΔBP (F[1,19]=3.86, p=0.064).
