Chunk #13 — Methods — The QTLD test

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The quantitative trait linkage disequilibrium test: a more powerful alternative to the quantitative transmission disequilibrium test for use in the absence of population stratification.

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In Models 1 through 4, the b and w components are defined according to the QTDT scheme, while in Models 5 and 6, the QTLD-defined components, b' and w', are used. All models are derived from a previously maximized model which includes the trait of interest, any relevant covariates, and a linkage component based on IBD allele-sharing estimated from a microsatellite genome scan.