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Chunk #0 — Background

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Ethanol-mediated activation of the NLRP3 inflammasome in iPS cells and iPS cells-derived neural progenitor cells.
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Alcohol use disorders (AUDs) are among the most common pathologies that affect the central nervous system (CNS). Fetal exposure to ethanol is known to cause long-term cognitive impairment and brain deficits [1, 2] that are commonly referred to as Fetal Alcohol Spectrum Disorders (FASDs). Despite a wide array of epidemiological studies that have investigated the genetic predisposition to develop AUDs, the cellular underpinnings and the pathophysiology of AUDs remain elusive in the CNS [3].