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Chunk #21 — Results — Hypothesis 1: associations between EXT PGS and externalizing behaviors — Adolescents

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Examining associations between genetic and neural risk for externalizing behaviors in adolescence and early adulthood.
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There was a significant association between the EXT PGS and externalizing behaviors among EA adolescents (βEA = 0.10, 95% CI 0.03–0.17; ΔR2 = 0.01, 95% CI 0.00–0.02; Table 2, Fig. 1a), such that individuals who scored higher on the EXT PGS also reported higher levels of externalizing behaviors. There was also a significant effect of sex (β = −0.09, 95% CI −0.16 to −0.02; Table 2), indicating that males endorsed higher levels of externalizing behaviors. However, when tested, there was no evidence of a significant EXT PGS by sex interaction (β = −0.01, 95% CI −0.07 to 0.07). The association between the EXT PGS and externalizing behavior scores was not significant for AA adolescents (β = −0.01, 95% CI −0.10 to 0.09; ΔR2 = 0.00, 95% CI −0.00 to 0.00; Table 2, Fig. 1b); however, there was a similar effect of sex, such that males endorsed higher levels of externalizing behaviors (β = −0.11, 95% CI −0.20 to −0.03; Table 2). When tested, there was no evidence of a significant EXT PGS by sex interaction among EA or AA adolescents (online Supplementary Table 3).