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Chunk #21 — Results — Replication of association in SAGE and OZALC studies

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A genome-wide association study of alcohol-dependence symptom counts in extended pedigrees identifies C15orf53.
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Sixty-nine of the 72 SNPs associated with SC (with inflation corrected p<10−4) in the COGA families were tested in OZALC. None of these SNPs showed association with SC in this sample (Table S2). Association of SNPs in the C15orf53 gene region (rs2132157, rs12916379 and rs12903120, with p=0.03, p=0.03, and p=0.05, respectively) was observed with DSM-IV AD but not with SC (data not shown).