Chunk #64 — Reversal of the maternal effect on GR expression and HPA responses to stress

Source

Environmental programming of stress responses through DNA methylation: life at the interface between a dynamic environment and a fixed genome.

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These findings suggest that maternal behavior produces an active demethylation process at selected and perhaps actively targeted sites. The resulting demethylation of the 5' CpG dinucleotide within the NGFIA response element of the exon 17 promoter enhances NGFIA binding to the exon 17 promoter, increasing GR gene transcription and HPA responses to stress.