previous GWASs, but rather the replicable risk regions. This idea was similar to that in a prior study [4]. In the replicable risk regions, there should be not only many individual markers replicable between the discovery and replication samples, but the overall distributions of association signals and functional signals throughout the whole region should also be consistent across the discovery, replication and confirmation samples (see rationales in Materials and Methods S1). Such important regions have not been reported in previous GWASs of alcohol dependence.
