(for review see Hicke, 1999). However, we were unable to block E-cadherin destruction in the p120 siRNA cell lines with either presenilin or tyrosine kinase inhibitors (unpublished data). Moreover, the mechanism we describe is common to several cadherins, whereas the Hakai mechanism appears specific for E-cadherin. Nonetheless, our data favor a model where an E-cadherin–targeting event is triggered by the absence or transient off-loading of p120.
