We assessed the pattern of genetic correlations of EXT-minus-23andMe with other traits and found this pattern to be nearly identical to that of the original study (Spearman r ~ 1) (Fig. 3, Table S5). Furthermore, none of the point estimates were statistically different. Thus, in our scenario, down-sampling did not meaningfully impact the genetic correlations with other traits, meaning that researchers interested in such analyses can safely proceed with using the down-sampled summary statistics.
