Chunk #96 — III. Selected Methodological Issues — B. Power assessments

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Molecular genetics of addiction and related heritable phenotypes: genome-wide association approaches identify "connectivity constellation" and drug target genes with pleiotropic effects.

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These power calculations apply only to the initial genome scans. As we note above, replicate studies aid in distinguishing false- from true positive associations, but also increase the cumulative number of false-negative results.