when applied to the full genome. Furthermore, we call the pPS calculated on ancestry specific portions of a given genome “ancestry-specific pPS” (aspPS). The model described above ignores entirely the problem of coupling the correct portions of the genome with the appropriate PS, especially important due to the unique tiling of ancestry blocks and with unequal genomic patterns of phenotypic association. We overcome this obstacle by defining the genomic subsets used to compute aspPS through an accurate local ancestry deconvolution process (Fig. 1).
