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Chunk #23 — MATERIAL AND METHODS — Caine criteria and thiamine measurement

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Neurological, nutritional and alcohol consumption factors underlie cognitive and motor deficits in chronic alcoholism.
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The four Caine criteria were quantified as previously described (Pitel et al., 2011): (1) Dietary Deficiency – reporting, in a clinical interview based on a timeline follow-back format, at least 30 days in their lifetime when they went the entire day without eating because of their active drinking, (2) Oculomotor Disturbance - exhibiting nystagmus on neurological examination, (3) Cerebellar Dysfunction - scoring at least 1.5 standard deviations below the mean for age- and sex-matched controls on at least 2 of the 4 balance and ataxia measures with eyes open (standing heel-to-toe on a line for 60 sec (Romberg), walking 10 steps on a line, balancing on the right leg for 30 sec, and balancing on the left leg for 30 sec) (Fregly, Smith, & Graybiel, 1973), and (4) Altered Mental State or Mild Cognitive Impairment - scoring below 124 out of 144 points on the Dementia Rating Scale (Mattis, 2004).