The “journey as well as destination” tenet also highlights the fundamentally dynamic nature of brain development, one of the most striking features of the human brain illuminated by pediatric neuroimaging. The ability of our brains to adapt and change based on the demands of environment is the hallmark of our species. Understanding the mechanisms and influences responsible for these changes may help us to harness the brain’s plasticity towards interventions for clinical disorders and optimizing the path to healthy development.