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Chunk #50 — METHODS — Cross-traits bubble plot

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Genetic studies of body mass index yield new insights for obesity biology.
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We also represent the genetic overlap between other cardiometabolic traits and BMI susceptibility loci with a bubble plot in which the size of each bubble is proportional to the fraction of BMI-associated loci for which there was a significant association (P < 5 × 10−4). Each pair of bubbles is connected by a line proportional to the number of significant BMI-increasing loci overlapping between the traits.