Chunk #27 — Methods — Simulation — Generating SNPs

Source

Dosage transmission disequilibrium test (dTDT) for linkage and association detection.

Embedded

yes

Text

Denote the haplotype frequencies of disease locus D and SNP locus S as h11, h12, h21 and h22. On condition of the child being affected, the probabilities of different haplotypes in a child can be calculated through: (19)