Chunk #42 — The search for gene variants related to alcohol sensitivity (See Table 1) — Additional genes of potential interest

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A Critical Review of Methods and Results in the Search for Genetic Contributors to Alcohol Sensitivity.

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Ryanodine 3 receptor-related genes (RYR, chromosome 15q13.3) potentially relate to single dose oral alcohol responses in humans, and homologs of this gene may relate to alcohol sensitivity in C. elegans (unc-68) and to tolerance development in Drosophila (Adkins et al., 2017; Joslyn et al., 2010). Ryanodine gene effects might operate, at least in part, through calcium channels and dopamine 1 receptors (Kurokawa et al., 2013).