We used the Heritability Estimator from Summary Statistics (HESS)48 method to estimate the genome-wide SNP heritability of our seven main phenotypes. For the results reported in Table 1, we used the summary statistics from the GWAS listed in the table for all 1000 Genomes phase 3 SNPs with MAF greater than 0.05. We did not apply GC prior to estimating heritability with HESS. The Supplementary Note, Supplementary Table 30, and Supplementary Fig. 14 provide additional details, and also report estimates of the SNP heritability of our seven main phenotypes estimated with the GCTA49, LD Score regression12, and HESS methods, using only summary statistics from the UKB GWAS for comparability across phenotypes and methods (except for adventurousness, which is not available in the UKB and for which we used the 23andMe summary statistics).
