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Chunk #21 — RESULTS — Gene Ontology categories enriched in each brain region

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Significant modulation of mitochondrial electron transport system by nicotine in various rat brain regions.
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phosphorylation) were induced. For the VTA, eight GO categories were upregulated, including those related to mitochondrial function (i.e., electron transport, mitochondrial respiratory chain complex I, mitochondrion, and proton-transporting two-sector ATPase complex), ion transport, small GTPase-mediated signal transduction, and two others (axon and cell adhesion). We also identified a few downregulated GO categories, including protein biosynthesis, protein complex, ribonucleoprotein complex, ribosome biogenesis and assembly, RNA binding, RNA splicing, and structural constituent of ribosome.