The F-SNP database is a comprehensive resource collecting computationally obtained functional information about SNPs. The information is given in four levels, namely, protein coding, splicing regulation, transcriptional regulation and post-translation. As effective association studies largely depend on prioritizing the SNPs to be examined and studied, we expect that F-SNP will serve as a one-stop tool for selecting potential disease-causing SNP markers for association studies. The functional information provided for SNPs will be regularly updated as other prediction tools and biomolecular experiments become available. We also plan to integrate additional human-disease databases to include a broader spectrum of common and complex diseases.