We performed hierarchical clustering on the 22 members of the HDAC inhibitor PCL in the space of their pairwise connectivities to each other across 9 cell lines using spearman correlation as the similarity metric with complete linkage. Hierarchical clustering of pairwise connectivities of the HDAC inhibitor PCL members reveals substructure within the class. The pan-HDAC inhibitors generally cluster together, distinct from the more isoform-selective compounds, suggesting that gene expression can be used to further stratify compounds within the same class.
