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Chunk #15 — METHODS — Association and Admixture Mapping

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Local and global ancestry inference and applications to genetic association analysis for admixed populations.
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Chen et al. [2013] used local ancestry estimates for admixture mapping with the real SBP and DBP phenotype data. Chen et al. [2013] performed the admixture mapping analysis using a linear regression model for the identification of SNPs with unusual deviations of European or Native American ancestry, relative to global ancestry estimates from these populations on chromosome 3. In addition to the admixture mapping analysis, Chen et al. [2013] also performed an association analysis with the blood pressure phenotypes, where a linear regression analysis was used to detect association between each of the SNPs and the SBP and DBP phenotypes, with local ancestry at a SNP included as a covariate to correct for population stratification.