Next, we tested whether Colorado differed from other regions of the country that were by 2011 not directly affected by medical marijuana laws. NMMS at that time included 34 states (see Supplemental Table 12 legend for a complete list). We compared Colorado and NMMS within each year pairing (e.g. 2003-4) for separate age groups (12-17 years, 18-25 years and 26 or older) for each outcome variable described above.