Chunk #101 — 7.0 Recommendations to Advance Endophenotype Genetics — 7.3 Adequate power to detect individual effects is crucial but almost never attained in existing endophenotype genetic association studies — 7.3.2 Power in GREML
the heritability of the two traits is similar affect power both positively and negatively, but the need for large samples is clear. When sufficiently powered, GREML analyses have the potential to provide insight into the genetic architecture of endophenotypes and the nature of their association with clinical phenotypes, but because neither individual SNPS nor genes are identified, they do not shed light on the specific nature of the genetic etiology.
