MAC for each mouse was calculated as the average of the bracketing concentrations. We computed the mean and SD for each of 10 groups of mice defined by strain (+/+ versus Lwt/+) and anesthetic (cyclopropane, halothane, isoflurane, and sevoflurane). We determined the significance of differences between strains for a given anesthetic using student's t-test, applying a Bonferroni correction for multiple (four) comparisons. Thus, a value of P<0.0125 was regarded as significant for all comparisons.
