The same analysis of locus 2 (tagging rs578776) yields a meta-analysis p-value of 1.38×10−25 and an OR of 0.78 (0.74–0.81), indicating a protective association for the minor allele as has previously been reported (Figure 2). Locus 3 (tagging rs588765) under the same model gives a p-value of 0.00027 and OR of 0.93 (0.89–0.97), which meets our threshold for multiple-test corrected significance but, unlike locus 1 and locus 2, does not surpass genome-wide significance (Figure 3). Locus 4 (tagging rs12914008) does not show a main effect on dichotomous CPD (p = 0.45, OR = 1.05 (0.93–1.17). The forest plot for locus 4 is given in Figure S2.
