Chunk #16 — Methods — Gene-based analysis, functional mapping and annotation of genome-wide association studies

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Sex differences in the genetic architecture of obsessive-compulsive disorder.

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if they fall within the gene start and end sites. In this analysis the mean of the chi2-statistic for the SNPs in a gene is calculated and the p-value is obtained from a known approximation of the sampling distribution (Brown 1975; Hou 2005). The genome-wide significance threshold is defined as 0.05 / number of genes to which the SNPs are mapped.