Monkeys and rats at NIDA-IRP were maintained in facilities fully accredited by AALAC, and all procedures were approved by the NIDA IACUC and conducted in accordance with the Guidelines of the National Research Council (2003). Rats in the electrophysiology study were maintained at the University of Cagliari, where all procedures were conducted in accordance with the European Economic Community Council Directive (86/609; DL27/01/92, no. 116).