Chunk #14 — METHODS — Coordinated meta-analysis process — VI. Models Analyzed

Source

Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression.

Embedded

yes

Text

The risk of depression displays an interaction between 5-HTTLPR genotype (LL, LS, SS) and exposure to stress: namely, the 5-HTTLPR genotype shows no association to depression in individuals not exposed to stress, but shows a dose response effect (increased risk for more copies of the S allele) in individuals exposed to stress. Our primary genetic coding was additive in the number of copies of the S allele. Our template for analysis is in the form