The NCI SciTS team, NCI program staff, and the TREC I Evaluation Working Group recognized that TREC I grantees were pioneers in using the TD team science approach in the obesity and cancer research fields, and in scientific research more broadly, whose lessons learned could benefit other investigators. They also wanted to learn more about TD team science processes and impacts in the context of a funding initiative such as TREC I that included structural elements expressly designed to facilitate TD team science. These interviews were conducted to document TREC I participants’ perspectives on lessons learned about engaging in TD team science as well as the broad impacts of TD team science conducted in the context of TREC I.