This study was supported by grants of the German Federal Ministry of Education and Research (BMBF 01KU0903; NGFNplus: 01GS0830, 01GS0820). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Funding to pay the Open Access publication charges for this article was provided by grants of the German Federal Ministry of Education and Research, NGFNplus: 01GS0830.