We also highlight convergent lines of evidence for a neurodevelopmental component in depression, emanating from: (i) novel loci (e.g. the top three novel loci located in genes associated with Mendelian neurodevelopmental disorders), (ii) pathway analyses showing enrichment of gene-sets related to neuronal development, (iii) enrichment of prenatal cell-types, (iv) association of depression genetic risk with attenuated cognitive performance in a community youth cohort and (v) MiXeR analyses showing substantial genetic overlap with autism, ADHD and schizophrenia. Although partly overlapping, these results implicate a role of neurodevelopmental processes in the etiology of depression.
